How do selective serotonin reuptake inhibitors (SSRIs) affect serotonin levels?

Selective serotonin reuptake inhibitors (SSRIs) work by increasing the levels of serotonin in the brain, which is crucial for mood regulation and is often linked to depression. They do this by blocking the reabsorption (or reuptake) of serotonin into the presynaptic neuron after it has been released into the synaptic cleft. Consequently, more serotonin remains available in the synaptic cleft to bind with postsynaptic receptors, enhancing its overall effects.

This mechanism is significant in treating depression and anxiety disorders, as it helps restore the balance of neurotransmitters in the brain. By increasing serotonin levels, SSRIs can help alleviate symptoms of depression, promoting a more stable mood and overall sense of well-being.