What physiological effect do CNS stimulants like amphetamines typically have on blood pressure?

CNS stimulants, such as amphetamines, typically increase blood pressure. This is primarily because they stimulate the central nervous system, leading to increased levels of neurotransmitters like norepinephrine and dopamine. The release of these neurotransmitters results in heightened cardiovascular activity, which includes increased heart rate and vasoconstriction, both of which contribute to elevated blood pressure.

While certain factors like dosage and individual patient characteristics might influence the degree of this response, the general pharmacological action of amphetamines is to elevate blood pressure. It's important to recognize that while there can be individual variability in response to these stimulants, the predominant and expected effect is an increase in blood pressure.